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Clinical rating scales for ataxia

Item Type:Article
Title:Clinical rating scales for ataxia
Creators Name:Schmitz-Hübsch, T.
Abstract:Clinical rating scales for ataxia yield a semi-quantitative measure of disease severity. Rating is based on standardized scoring, usually applied on standardized motor tests. Generic ataxia scales such as the International Cooperative Ataxia Rating Scale (ICARS) or the Scale for the Assessment and Rating of Ataxia (SARA) aim to assess ataxia independent of etiology. Disease-specific scales such as Friedreich Ataxia rating Scale (FARS) or the Unified Multiple Systems Atrophy Rating Scale (UMSARS) include a wider spectrum of specific features extending beyond ataxia. For use as an outcome in interventional trials, proof of reliability at retest is a prerequisite and prior data on the evolution of scores over time in the target group are useful for study planning. Remote application by video rating has been explored. Benchmarks of minimally important change or within-study validation against patient report are important to interpret the relevance of observed changes. Additional measures may be applied to capture treatment effects more comprehensively, for example, in the domains of executive functions, affect regulation, fatigue, or autonomic functions.
Keywords:Clinical Rating, SARA, FARS, ICARS, UMSARS, Responsiveness, Smallest Detectable Change, Minimally Important Difference, Timed Tests, Videorating
Source:Contemporary Clinical Neuroscience
Series Name:Contemporary Clinical Neuroscience
Title of Book:Trials for cerebellar ataxias : from cellular models to human therapies
Page Range:317-345
Date:30 May 2023
Official Publication:https://doi.org/10.1007/978-3-031-24345-5_10

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