Impact of structural differences in hyperbranched polyglycerol–polyethylene glycol nanoparticles on dermal drug delivery and biocompatibility

Item Type:	Article
Title:	Impact of structural differences in hyperbranched polyglycerol–polyethylene glycol nanoparticles on dermal drug delivery and biocompatibility
Creators Name:	Kumar, S. and Alnasif, N. and Fleige, E. and Kurniasih, I. and Kral, V. and Haase, A. and Luch, A. and Weindl, G. and Haag, R. and Schäfer-Korting, M. and Hedtrich, S.
Abstract:	Polyglycerol scaffolds and nanoparticles emerged as prominent material for various biomedical applications including topical drug delivery. The impact of slight structural modifications on the nanoparticles’ properties, drug delivery potential, and biocompatibility, however, is still not fully understood. Hence, we explored the influence of structural modifications of five structurally related polyglycerol-based nanoparticles (PG–PEG, SK1–SK5) on dermal drug delivery efficiency and biocompatibility. The PG–PEG particles were synthesized via randomly and controlled alkylated chemo-enzymatic approaches resulting in significantly varying particle sizes and interactions with guest molecules. Furthermore, we observed considerably improved dermal drug delivery with the smallest particles SK4 and SK5 (11 nm and 14 nm) which also correlated with well-defined surface properties achieved by the controlled alkylated synthesis approach. The consistently good biocompatibility for all PG–PEG particles was mainly attributed to the neutral surface charge. No irritation potential, major cytotoxicity or genotoxicity was observed. Nevertheless, slightly better biocompatibility was again seen for the particles characterized by alkyl chain substitution in the core and not on the particle surface. Despite the high structural similarity of the PG–PEG particles, the synthesis and the functionalization significantly influenced particle properties, biocompatibility, and most significantly the drug delivery efficiency.
Keywords:	Topical Drug Delivery, Hyperbranched Polyglycerol, PEG Nanoparticles, Structural Modifications, Biocompatibility, Nanotoxicology, Animals, Mice, Swine
Source:	European Journal of Pharmaceutics and Biopharmaceutics
ISSN:	0939-6411
Publisher:	Elsevier
Volume:	88
Number:	3
Page Range:	625-34
Date:	November 2014
Official Publication:	https://doi.org/10.1016/j.ejpb.2014.10.014
PubMed:	View item in PubMed

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