Core-multishell nanocarriers: transport and release of dexamethasone probed by soft x-ray spectromicroscopy

Item Type:	Article
Title:	Core-multishell nanocarriers: transport and release of dexamethasone probed by soft x-ray spectromicroscopy
Creators Name:	Yamamoto, K. and Klossek, A. and Flesch, R. and Ohigashi, T. and Fleige, E. and Rancan, F. and Frombach, J. and Vogt, A. and Blume-Peytavi, U. and Schrade, P. and Bachmann, S. and Haag, R. and Hedtrich, S. and Schäfer-Korting, M. and Kosugi, N. and Rühl, E.
Abstract:	Label-free detection of core-multishell (CMS) nanocarriers and the anti-inflammatory drug dexamethasone is reported. Selective excitation by tunable soft X-rays in the O 1s-regime is used for probing either the CMS nanocarrier or the drug. Furthermore, the drug loading efficiency into CMS nanocarriers is determined by X-ray spectroscopy. The drug-loaded nanocarriers were topically applied to human skin explants providing insights into the penetration and drug release processes. It is shown that the core-multishell nanocarriers remain in the stratum corneum when applied for 100 min to 1000 min. Dexamethasone, if applied topically to human ex vivo skin explants using different formulations, shows a vehicle-dependent penetration behavior. Highest local drug concentrations are found in the stratum corneum as well as in the viable epidermis. If the drug is loaded to core-multishell nanocarriers, the concentration of the free drug is low in the stratum corneum and is enhanced in the viable epidermis as compared to other drug formulations. The present results provide insights into the penetration of drug nanocarriers as well as the mechanisms of controlled drug release from CMS nanocarriers in human skin. They are also compared to related work using dye-labeled nanocarriers and dyes that were used as model drugs.
Keywords:	Drug Delivery, Core-multishell Nanocarriers, X-ray Microscopy, Human Skin
Source:	Journal of Controlled Release
ISSN:	0168-3659
Publisher:	Elsevier
Volume:	242
Page Range:	64-70
Date:	28 November 2016
Official Publication:	https://doi.org/10.1016/j.jconrel.2016.08.028
PubMed:	View item in PubMed

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