Stratum corneum targeting by dendritic core-multishell-nanocarriers in a mouse model of psoriasis

Item Type:	Article
Title:	Stratum corneum targeting by dendritic core-multishell-nanocarriers in a mouse model of psoriasis
Creators Name:	Pischon, H. and Radbruch, M. and Ostrowski, A. and Volz, P. and Gerecke, C. and Unbehauen, M. and Hönzke, S. and Hedtrich, S. and Fluhr, J.W. and Haag, R. and Kleuser, B. and Alexiev, U. and Gruber, A.D. and Mundhenk, L.
Abstract:	Inflammatory disorders of the skin pose particular therapeutic challenges due to complex structural and functional alterations of the skin barrier. Penetration of several anti-inflammatory drugs is particularly problematic in psoriasis, a common dermatitis condition with epidermal hyperplasia and hyperkeratosis. Here, we tested in vivo dermal penetration and biological effects of dendritic core-multishell-nanocarriers (CMS) in a murine skin model of psoriasis and compared it to healthy skin. In both groups, CMS exclusively localized to the stratum corneum of the epidermis with only very sporadic uptake by Langerhans cells. Furthermore, penetration into the viable epidermis of nile red as a model for lipophilic compounds was enhanced by CMS. CMS proved fully biocompatible in several in vitro assays and on normal and psoriatic mouse skin. The observations support the concept of CMS as promising candidates for drug delivery in inflammatory hyperkeratotic skin disorders in vivo.
Keywords:	CMS, Fluorescence Microscopy, FLIM, Mouse Model, Nile Red, Animals, Mice
Source:	Nanomedicine: Nanotechnology, Biology and Medicine
ISSN:	1549-9634
Publisher:	Elsevier
Volume:	13
Number:	1
Page Range:	317-327
Date:	January 2017
Official Publication:	https://doi.org/10.1016/j.nano.2016.09.004
PubMed:	View item in PubMed

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