pH-modulating poly(ethylene glycol)/alginate hydrogel dressings for the treatment of chronic wounds

Item Type:	Article
Title:	pH-modulating poly(ethylene glycol)/alginate hydrogel dressings for the treatment of chronic wounds
Creators Name:	Koehler, J. and Wallmeyer, L. and Hedtrich, S. and Goepferich, A.M. and Brandl, F.P.
Abstract:	The development of chronic wounds has been frequently associated with alkaline pH values. The application of pH-modulating wound dressings can, therefore, be a promising treatment option to promote normal wound healing. This study reports on the development and characterization of acidic hydrogel dressings based on interpenetrating poly(ethylene glycol) diacrylate/acrylic acid/alginate networks. The incorporation of ionizable carboxylic acid groups results in high liquid uptake up to 500%. The combination of two separate polymer networks significantly improves the tensile and compressive stability. In a 2D cell migration assay, the application of hydrogels (0% to 1.5% acrylic acid) results in complete "wound" closure; hydrogels with 0.25% acrylic acid significantly increase the cell migration velocity to 19.8 ± 1.9 µm h(-1). The most promising formulation (hydrogels with 0.25% acrylic acid) is tested on 3D human skin constructs, increasing keratinocyte ingrowth into the wound by 164%.
Keywords:	Chronic Wound, Hydrogels, Interpenetrating Networks (IPN), Reconstructed Human Skin, Wound Dressing
Source:	Macromolecular Bioscience
ISSN:	1616-5187
Publisher:	Wiley
Volume:	17
Number:	5
Page Range:	1600369
Date:	May 2017
Official Publication:	https://doi.org/10.1002/mabi.201600369
PubMed:	View item in PubMed

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