Alkaline poly(ethylene glycol)-based hydrogels for a potential use as bioactive wound dressings

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Item Type:	Article
Title:	Alkaline poly(ethylene glycol)-based hydrogels for a potential use as bioactive wound dressings
Creators Name:	Koehler, J., Verheyen, L., Hedtrich, S., Brandl, F.P. and Goepferich, A.M.
Abstract:	The number of patients with chronic wounds is increasing constantly in today's aging society. However, little work is done so far tackling the associated disadvantageous shift of the wound pH. In our study, we developed two different approaches on pH-modulating wound dressing materials, namely, bioactive interpenetrating polymer network hydrogels based on poly(ethylene glycol) diacrylate/N-vinylimidazole/alginate (named VIx) and poly(ethylene glycol) diacrylate/2-dimethylaminoethyl methacrylate/N-carboxyethylchitosan (named DMAEMAx). Both formulations showed a good cytocompatibility and wound healing capacity in vitro. The developed dressing materials significantly increased the cell ingrowth in wounded human skin constructs; by 364% and 313% for the VIx and the DMAEMAx hydrogel formulation, respectively. Additionally, VIx hydrogels were found to be suitable scaffolds for superficial cell attachment. Our research on the material properties suggests that ionic interactions and hydrogen bonds are the driving forces for the mechanical and swelling properties of the examined hydrogels. High amounts of positively charged amino groups in DMAEMAx hydrogels caused increased liquid uptake (around 190%), whereas VIx hydrogels showed a 10-fold higher maximum compressive stress in comparison to hydrogels without ionizable functional groups.
Keywords:	Cell Scaffold, Chronic Wound, Human Skin Construct, pH-Responsive Hydrogel, Wound Dressing
Source:	Journal of Biomedical Materials Research Part A
ISSN:	1552-4965
Publisher:	Wiley
Volume:	105
Number:	12
Page Range:	3360-3368
Date:	December 2017
Official Publication:	https://doi.org/10.1002/jbm.a.36177
PubMed:	View item in PubMed

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