The delivery challenge of genome editing in human epithelia

Item Type:	Article
Title:	The delivery challenge of genome editing in human epithelia
Creators Name:	Calderón, M. and Hedtrich, S.
Abstract:	Despite exciting advances in gene editing, their clinical translation is still hampered by the lack of delivery systems that can encapsulate and deliver gene editing tools like CRISPR-Cas9 or prime editors to the target side. This is particularly challenging in human epithelia, such as the skin and the lung; the latter of which being a mucosal surface that is covered by a mucus layer. In this perspective, the design and biological assessment of delivery systems for gene editing tools like CRISPR in skin and mucosal surfaces are discussed. The current state-of-the-art, current knowledge, and translational gaps, and guide toward improved translation are highlighted.
Keywords:	CRISPR-Cas, Gene Delivery, Gene Editing, Gene Therapy, Human Epithelia, Lungs, Skin
Source:	Advanced Healthcare Materials
ISSN:	2192-2659
Publisher:	Wiley
Volume:	10
Number:	19
Page Range:	e2100847
Date:	October 2021
Official Publication:	https://doi.org/10.1002/adhm.202100847
PubMed:	View item in PubMed

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