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Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology

Item Type:Article
Title:Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology
Creators Name:Abdelhak, A. and Solomon, I. and Montes, S.C. and Saias, A. and Cordano, C. and Asken, B. and Fonseca, C. and Oertel, F.C. and Arfanakis, K. and Staffaroni, A.M. and Kramer, J.H. and Geschwind, M. and Miller, B.L. and Elahi, F.M. and Green, A.J.
Abstract:INTRODUCTION: Development of novel diagnostic tools is a top research priority in vascular dementia. A major obstacle is the lack of a simple, non-invasive method to visualize cerebral arteriolar walls in vivo. Retinal arterioles offer a window into the cerebral circulation. METHODS: Intensity-based retinal arteriolar visualization in optical coherence tomography (I-bRAVO) was applied to evaluate mean wall thickness (MWT) and wall-to-lumen ratio (WLR) in 250 subjects with sporadic and genetic cerebral small vessel disease (CSVD), non-vascular neurodegenerative diseases (NVND), and healthy controls (HC) in association with imaging and cognitive markers. RESULTS: MWT and WLR were higher in CSVD, associated with severity of vascular white matter lesions, and correlated with magnetic resonance imaging-based intracranial arteriolosclerosis score. WLR correlated with gray and white matter volume and differentiated asymptomatic sporadic CSVD from HC (area under the curve = 0.82). DISCUSSION: I-bRAVO is a rapid, non-invasive tool. MWT and WLR were associated with imaging markers of CSVD and could contribute to early identification of sporadic CSVD.
Keywords:Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, Cerebral Small Vessel Disease, Retinal Vessels, Vascular Dementia, White Matter Disease
Source:Alzheimer's & Dementia: Diagnosis Assessment & Disease Monitoring
Page Range:e12338
Official Publication:https://doi.org/10.1002/dad2.12338
PubMed:View item in PubMed

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