Disentangling extrachromosomal circular DNA heterogeneity in single cells with scEC&T-seq

Item Type:	Editorial
Title:	Disentangling extrachromosomal circular DNA heterogeneity in single cells with scEC&T-seq
Creators Name:	Chamorro González, R. and Henssen, A.G.
Abstract:	We introduce scEC&T-seq, a new single-cell sequencing method that enables parallel profiling of extrachromosomal circular DNA and mRNAs in single cells. Using scEC&T-seq, we characterized all types of circular DNA elements in single human cancer cells and profiled the intercellular heterogeneity and structural dynamics of cancer-specific extrachromosomal DNA.
Keywords:	Circular DNA, DNA
Source:	Nature Genetics
ISSN:	1061-4036
Publisher:	Nature Publishing Group
Volume:	55
Number:	5
Page Range:	740-741
Date:	May 2023
Official Publication:	https://doi.org/10.1038/s41588-023-01385-z
PubMed:	View item in PubMed

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