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Integrated physiology of the exocrine and endocrine compartments in pancreatic diseases

Item Type:Article
Title:Integrated physiology of the exocrine and endocrine compartments in pancreatic diseases
Creators Name:Mastracci, T.L. and Apte, M. and Amundadottir, L.T. and Alvarsson, A. and Artandi, S. and Bellin, M.D. and Bernal-Mizrachi, E. and Caicedo, A. and Campbell-Thompson, M. and Cruz-Monserrate, Z. and El Ouaamari, A. and Gaulton, K.J. and Geisz, A. and Goodarzi, M.O. and Hara, M. and Hull-Meichle, R.L. and Kleger, A. and Klein, A.P. and Kopp, J.L. and Kulkarni, R.N. and Muzumdar, M.D. and Naren, A.P. and Oakes, S.A. and Olesen, S.S. and Phelps, E.A. and Powers, A.C. and Stabler, C.L. and Tirkes, T. and Whitcomb, D.C. and Yadav, D. and Yong, J. and Zaghloul, N.A. and Sander, M. and Pandol, S.J.
Abstract:The “Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases” Workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and basic science investigators interested in diseases of the pancreas. This report summarizes the workshop proceedings. The goal of the workshop was to forge connections and identify gaps in knowledge that could guide future research directions. Presentations were segregated into 6 major themes, including (a) Pancreas Anatomy and Physiology; (b) Diabetes in the Setting of Exocrine Disease; (c) Metabolic Influences on the Exocrine Pancreas; (d) Genetic Drivers of Pancreatic Diseases; (e) Tools for Integrated Pancreatic Analysis; and (f) Implications of Exocrine-Endocrine Crosstalk. For each theme, there were multiple presentations followed by panel discussions on specific topics relevant to each area of research; these are summarized herein. Significantly, the discussions resulted in the identification of research gaps and opportunities for the field to address. In general, it was concluded that as a pancreas research community, we must more thoughtfully integrate our current knowledge of the normal physiology as well as the disease mechanisms that underlie endocrine and exocrine disorders so that there is a better understanding of the interplay between these compartments.
Keywords:Diabetes Mellitus, Islets of Langerhans, Pancreas, Exocrine Pancreas, Pancreatic Diseases
Publisher:Lippincott Williams & Wilkins
Page Range:1061-1073
Date:1 October 2022
Official Publication:https://doi.org/10.1097/MPA.0000000000002170
PubMed:View item in PubMed

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