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Unwelcome guests – the role of gland-associated Helicobacter pylori infection in gastric carcinogenesis

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Item Type:Review
Title:Unwelcome guests – the role of gland-associated Helicobacter pylori infection in gastric carcinogenesis
Creators Name:Beccaceci, G. and Sigal, M.
Abstract:Helicobacter pylori (H. pylori) are Gram-negative bacteria that cause chronic gastritis and are considered the main risk factor for the development of gastric cancer. H. pylori have evolved to survive the harsh luminal environment of the stomach and are known to cause damage and signaling aberrations in gastric epithelial cells, which can result in premalignant and malignant pathology. As well as colonizing the gastric mucus and surface epithelial cells, a subpopulation of H. pylori can invade deep into the gastric glands and directly interact with progenitor and stem cells. Gland colonization therefore bears the potential to cause direct injury to long-lived cells. Moreover, this bacterial subpopulation triggers a series of host responses that cause an enhanced proliferation of stem cells. Here, we review recent insights into how gastric gland colonization by H. pylori is established, the resulting pro-carcinogenic epithelial signaling alterations, as well as new insights into stem cell responses to infection. Together these point towards a critical role of gland-associated H. pylori in the development of gastric cancer.
Keywords:Infection, Gastric Cancer, Epithelial Stem Cells, Gland-Associated Bacteria, Gland-Colonization, Animals, Mice
Source:Frontiers in Oncology
Publisher:Frontiers Media SA
Page Range:1171003
Date:21 April 2023
Official Publication:https://doi.org/10.3389/fonc.2023.1171003
PubMed:View item in PubMed

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