The lure of cardiac metabolism in the diagnosis, prevention, and treatment of heart failure

Item Type:	Review
Title:	The lure of cardiac metabolism in the diagnosis, prevention, and treatment of heart failure
Creators Name:	Rodolico, D. and Schiattarella, G.G. and Taegtmeyer, H.
Abstract:	Energy substrate metabolism and contractile function are tightly coupled in the heart. Within this framework, heart failure may be viewed as a state of impaired energy transfer. The metabolic changes in the failing heart are linked to functional and structural changes. A worthwhile goal is to measure metabolic flux and its regulation quantitatively, and to do this in a manner that leads to targeted interventions. For several good reasons, this goal has been elusive until now. The development of new analytical and imaging techniques offers the potential of exploring the landscape of metabolic changes across the different stages of heart failure. In this Review Topic of the Month, we focus on concepts and brevity to provide a strategic overview of cardiac metabolism in the diagnosis, prevention, and treatment of nonischemic heart failure.
Keywords:	Energy Metabolism, Heart, Heart Failure, Myocardium
Source:	JACC: Heart Failure
ISSN:	2213-1787
Publisher:	Elsevier
Volume:	11
Number:	6
Page Range:	637-645
Date:	June 2023
Official Publication:	https://doi.org/10.1016/j.jchf.2023.02.007
PubMed:	View item in PubMed

Repository Staff Only: item control page