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Influence of phosphorylation on intermediate filaments

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Item Type:Article
Title:Influence of phosphorylation on intermediate filaments
Creators Name:Kraxner, J. and Köster, S.
Abstract:The cytoskeleton of eukaryotes consists of actin filaments, microtubules and intermediate filaments (IF). IFs, in particular, are prone to pronounced phosphorylation, leading to additional charges on the affected amino acids. In recent years, a variety of experiments employing either reconstituted protein systems or living cells have revealed that these altered charge patterns form the basis for a number of very diverse cellular functions and processes, including reversible filament assembly, filament softening, network remodeling, cell migration, interactions with other protein structures, and biochemical signaling.
Keywords:Assembly and Disassembly, Cytoskeleton, Mechanics, Mitosis, Posttranslational Modification, Vimentin
Source:Biological Chemistry
ISSN:1431-6730
Publisher:de Gruyter
Volume:404
Number:8-9
Page Range:821-827
Date:20 April 2023
Official Publication:https://doi.org/10.1515/hsz-2023-0140
PubMed:View item in PubMed

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