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New insights from genetic studies of eczema

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Item Type:Article
Title:New insights from genetic studies of eczema
Creators Name:Marenholz, I. and Arnau-Soler, A. and Rosillo-Salazar, O.D. and Lee, Y.A.
Abstract:Genome-wide association studies (GWAS) provided fundamental insight into the genetic determinants of complex allergic diseases. For eczema, 58 susceptibility loci were reported. Protein-changing variants were associated with eczema at genome-wide significance at 12 loci. The majority of risk variants were, however, located in non-coding, regulatory regions of the genome. Prioritized target genes were enriched in pathways of the immune response and of epithelial barrier function. Interestingly, a large overlap in the genetic architecture underlying different allergic diseases was identified pointing to common pathomechanisms for eczema, asthma, hay fever, and food allergy. Here, we review the most recent findings from GWAS for eczema including the role of rare variants and genetic heterogeneity in ethnically diverse populations. In addition, we provide an overview of genes underlying Mendelian disorders featuring eczematous skin inflammation.
Keywords:Eczema, Atopic Dermatitis, Allergy, Filaggrin, Epidermal Differentiation Complex, Complex Disease, Genomewide Association Study, Rare Variants
Source:Medizinische Genetik
Publisher:de Gruyter
Page Range:33-45
Date:5 April 2023
Official Publication:https://doi.org/10.1515/medgen-2023-2010

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