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Sarcoma patients admitted to the intensive care unit (ICU): predictive relevance of common sepsis and performance parameters

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Item Type:Article
Title:Sarcoma patients admitted to the intensive care unit (ICU): predictive relevance of common sepsis and performance parameters
Creators Name:Striefler, J.K. and Binder, P.T. and Brandes, F. and Rau, D. and Wittenberg, S. and Kaul, D. and Roohani, S. and Jarosch, A. and Schäfer, F.M. and Öllinger, R. and Märdian, S. and Bullinger, L. and Eckardt, K.U. and Kruse, J. and Flörcken, A.
Abstract:PURPOSE: Prognosis of sarcoma patients is improving, with a better understanding of sarcomagenesis revealing novel therapeutic targets. However, aggressive chemotherapy remains an essential part of treatment, bearing the risk of severe side effects that require intensive medical treatment. Available data on the characteristics and clinical outcome of sarcoma patients admitted to intensive care units (ICU) are sparse. PATIENTS AND METHODS: We performed a retrospective analysis of sarcoma patients admitted to the ICU from 2005 to 2022. Patients =18 years with histologically proven sarcoma were included in our study. RESULTS: Sixty-six patients were eligible for analysis. The following characteristics had significant impact on overall survival: sex (p=0.046), tumour localization (p=0.02), therapeutic intention (p=0.02), line of chemotherapy (p<0.001), SAPS II score (p=0.03) and SOFA score (p=0.02). CONCLUSION: Our study confirms the predictive relevance of established sepsis and performance scores in sarcoma patients. For overall survival, common clinical characteristics are also of significant value. Further investigation is needed to optimize ICU treatment of sarcoma patients.
Keywords:Soft Tissue Sarcoma, Intensive Care Unit, Sepsis and Performance Scores, SOFA, SAPS II, ICU-Specific Survival
Source:Cancer Management and Research
Publisher:Dove Medical Press
Page Range:321-334
Date:27 March 2023
Official Publication:https://doi.org/10.2147/CMAR.S400430
PubMed:View item in PubMed

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