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Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters

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Item Type:Article
Title:Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters
Creators Name:Nouailles, G. and Adler, J.M. and Pennitz, P. and Peidli, S. and Teixeira Alves, L.G. and Baumgardt, M. and Bushe, J. and Voss, A. and Langenhagen, A. and Langner, C. and Martin Vidal, R. and Pott, F. and Kazmierski, J. and Ebenig, A. and Lange, M.V. and Mühlebach, M.D. and Goekeri, C. and Simmons, S. and Xing, N. and Abdelgawad, A. and Herwig, S. and Cichon, G. and Niemeyer, D. and Drosten, C. and Goffinet, C. and Landthaler, M. and Blüthgen, N. and Wu, H. and Witzenrath, M. and Gruber, A.D. and Praktiknjo, S.D. and Osterrieder, N. and Wyler, E. and Kunec, D. and Trimpert, J.
Abstract:Vaccines play a critical role in combating the COVID-19 pandemic. Future control of the pandemic requires improved vaccines with high efficacy against newly emerging SARS-CoV-2 variants and the ability to reduce virus transmission. Here we compare immune responses and preclinical efficacy of the mRNA vaccine BNT162b2, the adenovirus-vectored spike vaccine Ad2-spike and the live-attenuated virus vaccine candidate sCPD9 in Syrian hamsters, using both homogeneous and heterologous vaccination regimens. Comparative vaccine efficacy was assessed by employing readouts from virus titrations to single-cell RNA sequencing. Our results show that sCPD9 vaccination elicited the most robust immunity, including rapid viral clearance, reduced tissue damage, fast differentiation of pre-plasmablasts, strong systemic and mucosal humoral responses, and rapid recall of memory T cells from lung tissue after challenge with heterologous SARS-CoV-2. Overall, our results demonstrate that live-attenuated vaccines offer advantages over currently available COVID-19 vaccines.
Keywords:Live Attenuated Vaccines, Mucosal Immunology, SARS-CoV-2, Animals, Cricetinae
Source:Nature Microbiology
Publisher:Nature Publishing Group
Page Range:860-874
Date:May 2023
Official Publication:https://doi.org/10.1038/s41564-023-01352-8

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