Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration

[thumbnail of Original Article]
Preview
PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB
[thumbnail of Supplementary Information] Other (Supplementary Information)
4MB

Item Type:Article
Title:A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration
Creators Name:Löffler, J., Noom, A., Ellinghaus, A., Dienelt, A., Kempa, S. and Duda, G.N.
Abstract:Bone regeneration after fracture is a complex process with high and dynamic energy demands. The impact of metabolism on bone healing progression and outcome, however, is so far understudied. Our comprehensive molecular profiling reveals that central metabolic pathways, such as glycolysis and the citric acid cycle, are differentially activated between rats with successful or compromised bone regeneration (young versus aged female Sprague-Dawley rats) early in the inflammatory phase of bone healing. We also found that the citric acid cycle intermediate succinate mediates individual cellular responses and plays a central role in successful bone healing. Succinate induces IL-1β in macrophages, enhances vessel formation, increases mesenchymal stromal cell migration, and potentiates osteogenic differentiation and matrix formation in vitro. Taken together, metabolites-here particularly succinate-are shown to play central roles as signaling molecules during the onset of healing and in steering bone tissue regeneration.
Keywords:Bone Regeneration, Bone and Bones, Osteogenesis, Sprague-Dawley Rats, Succinates, Animals, Rats
Source:Communications Biology
ISSN:2399-3642
Publisher:Springer Nature
Volume:6
Number:1
Page Range:327
Date:27 March 2023
Official Publication:https://doi.org/10.1038/s42003-023-04652-1
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library