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Integrated physiology of the exocrine and endocrine compartments in pancreatic diseases: workshop proceedings

Item Type:Editorial
Title:Integrated physiology of the exocrine and endocrine compartments in pancreatic diseases: workshop proceedings
Creators Name:Mastracci, T.L. and Apte, M. and Amundadottir, L.T. and Alvarsson, A. and Artandi, S. and Bellin, M.D. and Bernal-Mizrachi, E. and Caicedo, A. and Campbell-Thompson, M. and Cruz-Monserrate, Z. and El Ouaamari, A. and Gaulton, K.J. and Geisz, A. and Goodarzi, M.O. and Hara, M. and Hull-Meichle, R.L. and Kleger, A. and Klein, A.P. and Kopp, J.L. and Kulkarni, R.N. and Muzumdar, M.D. and Naren, A.P. and Oakes, S.A. and Olesen, S.S. and Phelps, E.A. and Powers, A.C. and Stabler, C.L. and Tirkes, T. and Whitcomb, D.C. and Yadav, D. and Yong, Jing and Zaghloul, N.A. and Pandol, S.J. and Sander, M.
Abstract:The Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and basic science investigators interested in diseases of the pancreas. This report provides a summary of the proceedings from the workshop. The goals of the workshop were to forge connections and identify gaps in knowledge that could guide future research directions. Presentations were segregated into six major theme areas, including 1) pancreas anatomy and physiology, 2) diabetes in the setting of exocrine disease, 3) metabolic influences on the exocrine pancreas, 4) genetic drivers of pancreatic diseases, 5) tools for integrated pancreatic analysis, and 6) implications of exocrine-endocrine cross talk. For each theme, multiple presentations were followed by panel discussions on specific topics relevant to each area of research; these are summarized here. Significantly, the discussions resulted in the identification of research gaps and opportunities for the field to address. In general, it was concluded that as a pancreas research community, we must more thoughtfully integrate our current knowledge of normal physiology as well as the disease mechanisms that underlie endocrine and exocrine disorders so that there is a better understanding of the interplay between these compartments.
Keywords:Diabetes Mellitus, Exocrine Pancreas, Islets of Langerhans, Pancreas, Pancreatic Diseases
Publisher:American Diabetes Association
Page Range:433-448
Date:April 2023
Additional Information:Erratum in: Diabetes 72(8):1173.
Official Publication:https://doi.org/10.2337/db22-0942
PubMed:View item in PubMed

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