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Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window

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Item Type:Article
Title:Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window
Creators Name:Vagnozzi, A.N. and Moore, M.T. and López de Boer, R. and Agarwal, A. and Zampieri, N. and Landmesser, L.T. and Philippidou, P.
Abstract:Phrenic Motor Column (PMC) neurons are a specialized subset of motor neurons (MNs) that provide the only motor innervation to the diaphragm muscle and are therefore essential for survival. Despite their critical role, the mechanisms that control phrenic MN development and function are not well understood. Here, we show that catenin-mediated cadherin adhesive function is required for multiple aspects of phrenic MN development. Deletion of β- and γ-catenin from MN progenitors results in perinatal lethality and a severe reduction in phrenic MN bursting activity. In the absence of catenin signaling, phrenic MN topography is eroded, MN clustering is lost and phrenic axons and dendrites fail to grow appropriately. Despite the essential requirement for catenins in early phrenic MN development, they appear to be dispensable for phrenic MN maintenance, as catenin deletion from postmitotic MNs does not impact phrenic MN topography or function. Our data reveal a fundamental role for catenins in PMC development and suggest that distinct mechanisms are likely to control PMC maintenance.
Keywords:Cadherins, Catenins, Respiratory, Phrenic Motor Neurons, Breathing
Source:Frontiers in Neural Circuits
Publisher:Frontiers Media SA
Page Range:1121049
Date:21 February 2023
Official Publication:https://doi.org/10.3389/fncir.2023.1121049
PubMed:View item in PubMed

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