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| Item Type: | Article |
|---|---|
| Title: | Diagnostic value of intereye difference metrics for optic neuritis in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders |
| Creators Name: | Oertel, F.C. and Zimmermann, H.G. and Motamedi, S. and Chien, C. and Aktas, O. and Albrecht, P. and Ringelstein, M. and Dcunha, A. and Pandit, L. and Martinez-Lapiscina, E.H. and Sanchez-Dalmau, B. and Villoslada, P. and Palace, J. and Roca-Fernández, A. and Leite, M.I. and Sharma, S.M. and Leocani, L. and Pisa, M. and Radaelli, M. and Lana-Peixoto, M.A. and Fontenelle, M.A. and Havla, J. and Ashtari, F. and Kafieh, R. and Dehghani, A. and Pourazizi, M. and Marignier, R. and Cobo-Calvo, A. and Asgari, N. and Jacob, A. and Huda, S. and Mao-Draayer, Y. and Green, A.J. and Kenney, R. and Yeaman, M.R. and Smith, T.J. and Cook, L. and Brandt, A.U. and Paul, F. and Petzold, A. |
| Abstract: | BACKGROUND: The novel optic neuritis (ON) diagnostic criteria include intereye differences (IED) of optical coherence tomography (OCT) parameters. IED has proven valuable for ON diagnosis in multiple sclerosis but has not been evaluated in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders (AQP4+NMOSD). We evaluated the diagnostic accuracy of intereye absolute (IEAD) and percentage difference (IEPD) in AQP4+NMOSD after unilateral ON >6 months before OCT as compared with healthy controls (HC). METHODS: Twenty-eight AQP4+NMOSD after unilateral ON (NMOSD-ON), 62 HC and 45 AQP4+NMOSD without ON history (NMOSD-NON) were recruited by 13 centres as part of the international Collaborative Retrospective Study on retinal OCT in Neuromyelitis Optica study. Mean thickness of peripapillary retinal nerve fibre layer (pRNFL) and macular ganglion cell and inner plexiform layer (GCIPL) were quantified by Spectralis spectral domain OCT. Threshold values of the ON diagnostic criteria (pRNFL: IEAD 5 µm, IEPD 5%; GCIPL: IEAD: 4 µm, IEPD: 4%) were evaluated using receiver operating characteristics and area under the curve (AUC) metrics. RESULTS: The discriminative power was high for NMOSD-ON versus HC for IEAD (pRNFL: AUC 0.95, specificity 82%, sensitivity 86%; GCIPL: AUC 0.93, specificity 98%, sensitivity 75%) and IEPD (pRNFL: AUC 0.96, specificity 87%, sensitivity 89%; GCIPL: AUC 0.94, specificity 96%, sensitivity 82%). The discriminative power was high/moderate for NMOSD-ON versus NMOSD-NON for IEAD (pRNFL: AUC 0.92, specificity 77%, sensitivity 86%; GCIP: AUC 0.87, specificity 85%, sensitivity 75%) and for IEPD (pRNFL: AUC 0.94, specificity 82%, sensitivity 89%; GCIP: AUC 0.88, specificity 82%, sensitivity 82%). CONCLUSIONS: Results support the validation of the IED metrics as OCT parameters of the novel diagnostic ON criteria in AQP4+NMOSD. |
| Keywords: | Aquaporin 4, Aquaporins, Autoantibodies, Benchmarking, Neuromyelitis Optica, Optic Neuritis, Retrospective Studies, Optical Coherence Tomography / Methods |
| Source: | Journal of Neurology, Neurosurgery, and Psychiatry |
| ISSN: | 1468-330X |
| Publisher: | BMJ Publishing Group |
| Volume: | 94 |
| Number: | 7 |
| Page Range: | 560-566 |
| Date: | July 2023 |
| Official Publication: | https://doi.org/10.1136/jnnp-2022-330608 |
| PubMed: | View item in PubMed |
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