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| Item Type: | Article |
|---|---|
| Title: | Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptation |
| Creators Name: | Li, B. and Zeis, P. and Zhang, Y. and Alekseenko, A. and Fürst, E. and Sanchez, Y.P. and Lin, G. and Tekkedil, M.M. and Piazza, I. and Steinmetz, L.M. and Pelechano, V. |
| Abstract: | Transcriptional memory, by which cells respond faster to repeated stimuli, is key for cellular adaptation and organism survival. Chromatin organization has been shown to play a role in the faster response of primed cells. However, the contribution of post-transcriptional regulation is not yet explored. Here we perform a genome-wide screen to identify novel factors modulating transcriptional memory in S. cerevisiae in response to galactose. We find that depletion of the nuclear RNA exosome increases GAL1 expression in primed cells. Our work shows that gene-specific differences in intrinsic nuclear surveillance factor association can enhance both gene induction and repression in primed cells. Finally, we show that primed cells present altered levels of RNA degradation machinery and that both nuclear and cytoplasmic mRNA decay modulate transcriptional memory. Our results demonstrate that mRNA post-transcriptional regulation, and not only transcription regulation, should be considered when investigating gene expression memory. |
| Keywords: | Epigenetics, RNA Decay, Transcriptomics |
| Source: | Nature Communications |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Volume: | 14 |
| Number: | 1 |
| Page Range: | 910 |
| Date: | 17 February 2023 |
| Official Publication: | https://doi.org/10.1038/s41467-023-36586-x |
| PubMed: | View item in PubMed |
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