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Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptation

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Item Type:Article
Title:Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptation
Creators Name:Li, B., Zeis, P., Zhang, Y., Alekseenko, A., Fürst, E., Sanchez, Y.P., Lin, G., Tekkedil, M.M., Piazza, I., Steinmetz, L.M. and Pelechano, V.
Abstract:Transcriptional memory, by which cells respond faster to repeated stimuli, is key for cellular adaptation and organism survival. Chromatin organization has been shown to play a role in the faster response of primed cells. However, the contribution of post-transcriptional regulation is not yet explored. Here we perform a genome-wide screen to identify novel factors modulating transcriptional memory in S. cerevisiae in response to galactose. We find that depletion of the nuclear RNA exosome increases GAL1 expression in primed cells. Our work shows that gene-specific differences in intrinsic nuclear surveillance factor association can enhance both gene induction and repression in primed cells. Finally, we show that primed cells present altered levels of RNA degradation machinery and that both nuclear and cytoplasmic mRNA decay modulate transcriptional memory. Our results demonstrate that mRNA post-transcriptional regulation, and not only transcription regulation, should be considered when investigating gene expression memory.
Keywords:Epigenetics, RNA Decay, Transcriptomics
Source:Nature Communications
ISSN:2041-1723
Publisher:Nature Publishing Group
Volume:14
Number:1
Page Range:910
Date:17 February 2023
Official Publication:https://doi.org/10.1038/s41467-023-36586-x
PubMed:View item in PubMed

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