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| Item Type: | Article |
|---|---|
| Title: | A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer |
| Creators Name: | Wu, Y. and Biswas, D. and Usaite, I. and Angelova, M. and Boeing, S. and Karasaki, T. and Veeriah, S. and Czyzewska-Khan, J. and Morton, C. and Joseph, M. and Hessey, S. and Reading, J. and Georgiou, A. and Al-Bakir, M. and McGranahan, N. and Jamal-Hanjani, M. and Hackshaw, A. and Quezada, S.A. and Hayday, A.C. and Swanton, C. |
| Abstract: | Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident γδ cells are less well defined. In the present study, we show that human lung tissues harbor a resident Vδ1 γδ T cell population. Moreover, we demonstrate that Vδ1 T cells with resident memory and effector memory phenotypes were enriched in lung tumors compared with nontumor lung tissues. Intratumoral Vδ1 T cells possessed stem-like features and were skewed toward cytolysis and helper T cell type 1 function, akin to intratumoral natural killer and CD8(+) T cells considered beneficial to the patient. Indeed, ongoing remission post-surgery was significantly associated with the numbers of CD45RA(-)CD27(-) effector memory Vδ1 T cells in tumors and, most strikingly, with the numbers of CD103(+) tissue-resident Vδ1 T cells in nonmalignant lung tissues. Our findings offer basic insights into human body surface immunology that collectively support integrating Vδ1 T cell biology into immunotherapeutic strategies for nonsmall cell lung cancer. |
| Keywords: | Cancer, Gammadelta T Cells, Non-Small-Cell Lung Cancer, Tumour Immunology, Animals, Mice |
| Source: | Nature Cancer |
| ISSN: | 2662-1347 |
| Publisher: | Springer Nature |
| Volume: | 3 |
| Number: | 6 |
| Page Range: | 696-709 |
| Date: | June 2022 |
| Additional Information: | Roland Schwarz, Tom L. Kaufmann and Mattthew Huska are members of the TRACERx Consortium. |
| Official Publication: | https://doi.org/10.1038/s43018-022-00376-z |
| PubMed: | View item in PubMed |
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