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| Item Type: | Article |
|---|---|
| Title: | Immunohistochemical analysis of nicotinamide phosphoribosyltransferase expression in gastric and esophageal adenocarcinoma (AEG) |
| Creators Name: | Arnold, A. and von Winterfeld, M. and Berg, E. and Hummel, M. and Rau, B. and Krenzien, F. and Stein, U. and Treese, C. |
| Abstract: | Nicotinamide phosphoribosyltransferase (NAMPT) represents a major component in cellular energy metabolism, which is also crucial for cancer cells that have elevated aerobic glycolysis; moreover, targeting the NAD salvage pathway by inhibition of NAMPT was shown effective in a subgroup of gastric cancer cell lines. In order to study the expression levels of NAMPT in adenocarcinoma of the esophagogastric junction and stomach (AEG/S) we performed immunohistochemical analysis in a cohort of 296 tumor samples using tissue-microarrays (TMAs). In the present investigation, we saw a high expression of NAMPT in only a minority of our large AEG/S cohort. Although we did not find a correlation between NAMPT expression and survival, subgroup analysis showed that NAMPT expression was more frequent in older patients (>65 years, p = 0.049) and was associated with a numerical shorter survival that did not reach statistical significance within this age group. In conclusion, we did not find significance for any prognostic effect of NAMPT in our AEG/S cohort; however, the evaluation of other NAD metabolic enzymes is needed as molecular predictors of response to potential NAMPT inhibition in the treatment of patients with AEG/S. |
| Keywords: | Gastric Cancer, Esophageal Cancer, Prognostic Biomarker, NAMPT |
| Source: | Gastrointestinal Disorders |
| ISSN: | 2624-5647 |
| Publisher: | MDPI |
| Volume: | 4 |
| Number: | 4 |
| Page Range: | 333-340 |
| Date: | 13 December 2022 |
| Official Publication: | https://doi.org/10.3390/gidisord4040031 |
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