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| Item Type: | Article |
|---|---|
| Title: | Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - a comparison to the EWGSOP2 cut-off points |
| Creators Name: | Huemer, M.T. and Kluttig, A. and Fischer, B. and Ahrens, W. and Castell, S. and Ebert, N. and Gastell, S. and Jöckel, K.H. and Kaaks, R. and Karch, A. and Keil, T. and Kemmling, Y. and Krist, L. and Leitzmann, M. and Lieb, W. and Meinke-Franze, C. and Michels, K.B. and Mikolajczyk, R. and Moreno Velásquez, I. and Pischon, T. and Schipf, S. and Schmidt, B. and Schöttker, B. and Schulze, M.B. and Stocker, H. and Teismann, H. and Wirkner, K. and Drey, M. and Peters, A. and Thorand, B. |
| Abstract: | BACKGROUND: The European Working Group on Sarcopenia in Older People (EWGSOP) updated in 2018 the cut-off points for low grip strength to assess sarcopenia based on pooled data from 12 British studies. OBJECTIVE: Comparison of the EWGSOP2 cut-off points for low grip strength to those derived from a large German sample. METHODS: We assessed the grip strength distribution across age and derived low grip strength cut-off points for men and women (peak mean -2.5 × SD) based on 200,389 German National Cohort (NAKO) participants aged 19-75 years. In 1,012 Cooperative Health Research in the Region of Augsburg (KORA)-Age participants aged 65-93 years, we calculated the age-standardised prevalence of low grip strength and time-dependent sensitivity and specificity for all-cause mortality. RESULTS: Grip strength increased in the third and fourth decade of life and declined afterwards. Calculated cut-off points for low grip strength were 29 kg for men and 18 kg for women. In KORA-Age, the age-standardised prevalence of low grip strength was 1.5× higher for NAKO-derived (17.7%) compared to EWGSOP2 (11.7%) cut-off points. NAKO-derived cut-off points yielded a higher sensitivity and lower specificity for all-cause mortality. CONCLUSIONS: Cut-off points for low grip strength from German population-based data were 2 kg higher than the EWGSOP2 cut-off points. Higher cut-off points increase the sensitivity, thereby suggesting an intervention for more patients at risk, while other individuals might receive additional diagnostics/treatment without the urgent need. Research on the effectiveness of intervention in patients with low grip strength defined by different cut-off points is needed. |
| Keywords: | Grip Strength, Probable Sarcopenia, European Working Group on Sarcopenia in Older People (EWGSOP), Mortality, Cut-Off Points |
| Source: | Age and Ageing |
| ISSN: | 1468-2834 |
| Publisher: | Oxford University Press |
| Volume: | 52 |
| Number: | 1 |
| Page Range: | afac324 |
| Date: | January 2023 |
| Official Publication: | https://doi.org/10.1093/ageing/afac324 |
| PubMed: | View item in PubMed |
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