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Mesoangioblasts at 20: from the embryonic aorta to the patient bed

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Item Type:Review
Title:Mesoangioblasts at 20: from the embryonic aorta to the patient bed
Creators Name:Cossu, G. and Tonlorenzi, R. and Brunelli, S. and Sampaolesi, M. and Messina, G. and Azzoni, E. and Benedetti, S. and Biressi, S. and Bonfanti, C. and Bragg, L. and Camps, J. and Cappellari, O. and Cassano, M. and Ciceri, F. and Coletta, M. and Covarello, D. and Crippa, S. and Cusella-De Angelis, M.G. and De Angelis, L. and Dellavalle, A. and Diaz-Manera, J. and Galli, D. and Galli, F. and Gargioli, C. and Gerli, M.F.M. and Giacomazzi, G. and Galvez, B.G. and Hoshiya, H. and Guttinger, M. and Innocenzi, A. and Minasi, M.G. and Perani, L. and Previtali, S.C. and Quattrocelli, M. and Ragazzi, M. and Roostalu, U. and Rossi, G. and Scardigli, R. and Sirabella, D. and Tedesco, F.S. and Torrente, Y. and Ugarte, G.
Abstract:In 2002 we published an article describing a population of vessel-associated progenitors that we termed mesoangioblasts (MABs). During the past decade evidence had accumulated that during muscle development and regeneration things may be more complex than a simple sequence of binary choices (e.g., dorsal vs. ventral somite). LacZ expressing fibroblasts could fuse with unlabelled myoblasts but not among themselves or with other cell types. Bone marrow derived, circulating progenitors were able to participate in muscle regeneration, though in very small percentage. Searching for the embryonic origin of these progenitors, we identified them as originating at least in part from the embryonic aorta and, at later stages, from the microvasculature of skeletal muscle. While continuing to investigate origin and fate of MABs, the fact that they could be expanded in vitro (also from human muscle) and cross the vessel wall, suggested a protocol for the cell therapy of muscular dystrophies. We tested this protocol in mice and dogs before proceeding to the first clinical trial on Duchenne Muscular Dystrophy patients that showed safety but minimal efficacy. In the last years, we have worked to overcome the problem of low engraftment and tried to understand their role as auxiliary myogenic progenitors during development and regeneration.
Keywords:Mesoderm, Myogenic Stem Cells, Pericyte, Muscular Dystrophy, Muscle Development
Source:Frontiers in Genetics
Publisher:Frontiers Media SA
Page Range:1056114
Date:4 January 2023
Official Publication:https://doi.org/10.3389/fgene.2022.1056114
PubMed:View item in PubMed

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