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Airway microbiome-immune crosstalk in chronic obstructive pulmonary disease

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Item Type:Review
Title:Airway microbiome-immune crosstalk in chronic obstructive pulmonary disease
Creators Name:Kayongo, A. and Robertson, N.M. and Siddharthan, T. and Ntayi, M.L. and Ndawula, J.C. and Sande, O.J. and Bagaya, B.S. and Kirenga, B. and Mayanja-Kizza, H. and Joloba, M.L. and Forslund, S.K.
Abstract:Chronic Obstructive Pulmonary Disease (COPD) has significantly contributed to global mortality, with three million deaths reported annually. This impact is expected to increase over the next 40 years, with approximately 5 million people predicted to succumb to COPD-related deaths annually. Immune mechanisms driving disease progression have not been fully elucidated. Airway microbiota have been implicated. However, it is still unclear how changes in the airway microbiome drive persistent immune activation and consequent lung damage. Mechanisms mediating microbiome-immune crosstalk in the airways remain unclear. In this review, we examine how dysbiosis mediates airway inflammation in COPD. We give a detailed account of how airway commensal bacteria interact with the mucosal innate and adaptive immune system to regulate immune responses in healthy or diseased airways. Immune-phenotyping airway microbiota could advance COPD immunotherapeutics and identify key open questions that future research must address to further such translation.
Keywords:COPD, Lung Microbiome, Mucosal Immunity, Inflammation, Innate Immunity, Adaptive Immunity
Source:Frontiers in Immunology
Publisher:Frontiers Media SA
Page Range:1085551
Date:17 January 2023
Official Publication:https://doi.org/10.3389/fimmu.2022.1085551
PubMed:View item in PubMed

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