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The NF-kappaB precursor p105 and the proto-oncogene product Bcl- 3 are I kappa B molecules and control nuclear translocation of NF-kappa B

Item Type:Article
Title:The NF-kappaB precursor p105 and the proto-oncogene product Bcl- 3 are I kappa B molecules and control nuclear translocation of NF-kappa B
Creators Name:Naumann, M. and Wulczyn, F.G. and Scheidereit, C.
Abstract:We have examined the interaction of the NF-kappa B precursor p105 with NF-kappa B subunits. Similar to an I kappa B molecule, p105 associates in the cytoplasm with p50 or p65. Through this assembly, p105 efficiently blocks nuclear transfer of either subunit. Moreover, the p105 protein inhibits DNA binding of dimeric NF-kappa B subunits in a similar, but not identical, manner to its isolated C-terminal domain, which contains an ankyrin-like repeat domain (ARD). The proto-oncogene product Bcl-3 also controls nuclear translocation of p50, but not of p65. Hence, p50 can be retained in the cytoplasm via at least three distinct interactions: through direct interactions either with its own precursor, with Bcl-3 or indirectly through I kappa B alpha or -beta when attached to p65. We discuss a function of p105 as a cytoplasmic assembly unit for homo- and heteromeric NF-kappa B complexes and of Bcl-3 as an I kappa B with novel subunit specificity.
Keywords:bcl-3, I kappa B, NF-kappa B Precursor p105, Nuclear Translocation, Proto-Oncogene, Animals
Source:EMBO Journal
ISSN:0261-4189
Publisher:Nature Publishing Group (U.S.A.)
Volume:12
Number:1
Page Range:213-222
Date:January 1993
Official Publication:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC413194/
PubMed:View item in PubMed

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