Helmholtz Gemeinschaft


Arterial myogenic response and aging

Item Type:Review
Title:Arterial myogenic response and aging
Creators Name:Cui, Y. and Gollasch, M. and Kassmann, M.
Abstract:The arterial myogenic response is an inherent property of resistance arteries. Myogenic tone is crucial for maintaining a relatively constant blood flow in response to changes in intraluminal pressure and protects delicate organs from excessive blood flow. Although this fundamental physiological phenomenon has been extensively studied, the underlying molecular mechanisms are largely unknown. Recent studies identified a crucial role of mechano-activated angiotensin II type 1 receptors (AT1R) in this process. The development of myogenic response is affected by aging. In this review, we summarize recent progress made to understand the role of AT1R and other mechanosensors in the control of arterial myogenic response. We discuss age-related alterations in myogenic response and possible underlying mechanisms and implications for healthy aging.
Keywords:Myogenic Response, Aging, Vascular Smooth Muscle, Ion Channels, Animals, Mice
Source:Ageing Research Reviews
Page Range:101813
Date:February 2023
Official Publication:https://doi.org/10.1016/j.arr.2022.101813
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library