Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Pseudocholinesterase as a biomarker for untreated Wilson's disease

[thumbnail of Original Article]
Preview
PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB

Item Type:Article
Title:Pseudocholinesterase as a biomarker for untreated Wilson's disease
Creators Name:Hefter, H., Arslan, M., Kruschel, T.S., Novak, M., Rosenthal, D., Meuth, S.G., Albrecht, P., Hartmann, C.J. and Samadzadeh, S.
Abstract:The aim of this study was to demonstrate that pseudocholinesterase (CHE) serum level is a useful diagnostic biomarker for untreated Wilson's disease (WD). Between 2013 and 2019, about 75 patients were referred to the outpatient department of the University of Düsseldorf with suspected Wilson's disease. In 31 patients with suspected Wilson's disease (WD-SUS-group), WD was excluded by means of investigations other than analysis of blood and urine. A total of 27 parameters of blood and urine in these 31 patients were compared to those of 20 de novo patients with manifest WD (WD-DEF-group), which parameter showed the highest significance level of difference between the WD-DEF-group and the WD-SUS-group. Thereafter, receiver operating characteristics (ROC-curves) were analyzed to evaluate which parameter showed the largest area under the curve (AUC) to detect WD. Finally, a logistic regression analysis was performed to analyze which combination of parameters allowed the best classification of the 51 patients either into the WD-DEF-group or into the WD-SUS-group. CHE showed the highest significance level for a difference between the WD-DEF- and WD-SUS-group, had the highest AUC, and, in combination with ceruloplasmin, allowed 100% correct classification. Without CHE, no other combination of parameters reached this level of correct classification. After the initiation of treatment, which regularly results in an improvement in CHE, the high diagnostic accuracy of this biomarker was lost. Cholinesterase turns out to be an excellent biomarker for differentiation between untreated de novo patients with manifest WD and heterozygotic gene carriers.
Keywords:Wilson’s Disease, Cholinesterase, Biomarker, Heterozygotic Gene Carriers, Diagnosis of Wilson’s Disease
Source:Biomolecules
ISSN:2218-273X
Publisher:MDPI
Volume:12
Number:12
Page Range:1791
Date:December 2022
Official Publication:https://doi.org/10.3390/biom12121791
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library