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Parametric MRI detects aristolochic acid induced acute kidney injury

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Item Type:Article
Title:Parametric MRI detects aristolochic acid induced acute kidney injury
Creators Name:Mei, Y. and Yang, G. and Guo, Y. and Zhao, K. and Wu, S. and Xu, Z. and Zhou, S. and Yan, C. and Seeliger, E. and Niendorf, T. and Xu, Y. and Feng, Y.
Abstract:Exposure to aristolochic acid (AA) is of increased concern due to carcinogenic and nephrotoxic effects, and incidence of aristolochic acid nephropathy (AAN) is increasing. This study characterizes renal alterations during the acute phase of AAN using parametric magnetic resonance imaging (MRI). An AAN and a control group of male Wistar rats received administration of aristolochic acid I (AAI) and polyethylene glycol (PEG), respectively, for six days. Both groups underwent MRI before and 2, 4 and 6 days after AAI or PEG administration. T(2) relaxation times and apparent diffusion coefficients (ADCs) were determined for four renal layers. Serum creatinine levels (sCr) and blood urea nitrogen (BUN) were measured. Tubular injury scores (TIS) were evaluated based on histologic findings. Increased T(2) values were detected since day 2 in the AAN group, but decreased ADCs and increased sCr levels and BUN were not detected until day 4. Significant linear correlations were observed between T(2) of the cortex and the outer stripe of outer medulla and TIS. Our results demonstrate that parametric MRI facilitates early detection of renal injury induced by AAI in a rat model. T(2) mapping may be a valuable tool for assessing kidney injury during the acute phase of AAN.
Keywords:Magnetic Resonance Imaging, T2 Mapping, Diffusion Weighted Imaging, Aristolochic Acid, Acute Kidney Injury, Animals, Rats
Publisher:Grapho Publications
Page Range:2902-2914
Date:10 December 2022
Official Publication:https://doi.org/10.3390/tomography8060243
PubMed:View item in PubMed

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