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Diverse effects of obesity on antitumor immunity and immunotherapy

Item Type:Review
Title:Diverse effects of obesity on antitumor immunity and immunotherapy
Creators Name:Dyck, L. and Lynch, L.
Abstract:Currently, obesity is one of the biggest health burdens facing society because it causes several comorbidities, such as type 2 diabetes, atherosclerosis, and heart disease. Obesity is also linked to multiple types of cancer. Obesity is the second most common preventable cause of cancer after smoking; the rates of obesity are increasing worldwide, as are the rates of obesity-associated cancer. Multiple factors link obesity to cancer, such as increased levels of growth hormones and adipokines, gut dysbiosis, altered tumor metabolism, and chronic low-grade inflammation. More recently, obesity has been shown to also affect the immune response against cancer. In this review we discuss the interplay between obesity, the immune system, and cancer.
Keywords:Antitumor Immunity, Cancer, Immunometabolism, Immunotherapy, Obesity
Source:Trends in Molecular Medicine
Publisher:Cell Press / Elsevier
Page Range:112-123
Date:February 2023
Official Publication:https://doi.org/10.1016/j.molmed.2022.11.004
PubMed:View item in PubMed

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