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Curvature in biological systems: its quantification, emergence and implications across the scales

Item Type:Article
Title:Curvature in biological systems: its quantification, emergence and implications across the scales
Creators Name:Schamberger, B. and Roschger, A. and Ziege, R. and Anselme, K. and Amar, M.B. and Bykowski, M. and Castro, A.P.G. and Cipitria, A. and Coles, R. and Dimova, R. and Eder, M. and Ehrig, S. and Escudero, L.M. and Evans, M.E. and Fernandes, P.R. and Fratzl, P. and Geris, L. and Gierlinger, N. and Hannezo, E. and Iglič, A. and Kirkensgaard, J.J.K. and Kollmannsberger, P. and Kowalewska, Ł. and Kurniawan, N.A. and Papantoniou, I. and Pieuchot, L. and Pires, T.H.V. and Renner, L. and Sageman-Furnas, A. and Schröder-Turk, G.E. and Sengupta, A. and Sharma, V.R. and Tagua, A. and Tomba, C. and Trepat, X. and Waters, S.L. and Yeo, E. and Bidan, C.M. and Dunlop, J.W.C.
Abstract:Surface curvature both emerges from, and influences the behavior of, living objects at length scales ranging from cell membranes to single cells to tissues and organs. The relevance of surface curvature in biology has been supported by numerous recent experimental and theoretical investigations in recent years. In this review, we first give a brief introduction to the key ideas of surface curvature in the context of biological systems and discuss the challenges that arise when measuring surface curvature. Giving an overview of the emergence of curvature in biological systems, its significance at different length scales becomes apparent. On the other hand, summarizing current findings also shows that both single cells and entire cell sheets, tissues or organisms respond to curvature by modulating their shape and their migration behavior. Finally, we address the interplay between the distribution of morphogens or micro-organisms and the emergence of curvature across length scales with examples demonstrating these key mechanistic principles of morphogenesis. Overall, this review highlights that curved interfaces are not merely a passive by-product of the chemical, biological and mechanical processes but that curvature acts also as a signal that co-determines these processes. This article is protected by copyright. All rights reserved.
Keywords:Curvature, Biology, Morphogenesis, Mechanotransduction
Source:Advanced Materials
ISSN:0935-9648
Publisher:Wiley
Page Range:e2206110
Date:3 December 2022
Official Publication:https://doi.org/10.1002/adma.202206110
PubMed:View item in PubMed

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