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Cell type diversity in a developing octopus brain

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Item Type:Article
Title:Cell type diversity in a developing octopus brain
Creators Name:Styfhals, R. and Zolotarov, G. and Hulselmans, G. and Spanier, K.I. and Poovathingal, S. and Elagoz, A.M. and De Winter, S. and Deryckere, A. and Rajewsky, N. and Ponte, G. and Fiorito, G. and Aerts, S. and Seuntjens, E.
Abstract:Octopuses are mollusks that have evolved intricate neural systems comparable with vertebrates in terms of cell number, complexity and size. The brain cell types that control their sophisticated behavioral repertoire are still unknown. Here, we profile the cell diversity of the paralarval Octopus vulgaris brain to build a cell type atlas that comprises mostly neural cells, but also multiple glial subtypes, endothelial cells and fibroblasts. We spatially map cell types to the vertical, subesophageal and optic lobes. Investigation of cell type conservation reveals a shared gene signature between glial cells of mouse, fly and octopus. Genes related to learning and memory are enriched in vertical lobe cells, which show molecular similarities with Kenyon cells in Drosophila. We construct a cell type taxonomy revealing transcriptionally related cell types, which tend to appear in the same brain region. Together, our data sheds light on cell type diversity and evolution in the octopus brain.
Keywords:Brain, Endothelial Cells, Neuroglia, Octopodiformes, Seafood, Animals, Drosophila, Mice
Source:Nature Communications
Publisher:Nature Publishing Group
Page Range:7392
Date:30 November 2022
Official Publication:https://doi.org/10.1038/s41467-022-35198-1
PubMed:View item in PubMed

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