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MicroRNAs are deeply linked to the emergence of the complex octopus brain

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Item Type:Article
Title:MicroRNAs are deeply linked to the emergence of the complex octopus brain
Creators Name:Zolotarov, G. and Fromm, B. and Legnini, I. and Ayoub, S. and Polese, G. and Maselli, V. and Chabot, P.J. and Vinther, J. and Styfhals, R. and Seuntjens, E. and Di Cosmo, A. and Peterson, K.J. and Rajewsky, N.
Abstract:Soft-bodied cephalopods such as octopuses are exceptionally intelligent invertebrates with a highly complex nervous system that evolved independently from vertebrates. Because of elevated RNA editing in their nervous tissues, we hypothesized that RNA regulation may play a major role in the cognitive success of this group. We thus profiled messenger RNAs and small RNAs in three cephalopod species including 18 tissues of the (Octopus vulgaris). We show that the major RNA innovation of soft-bodied cephalopods is an expansion of the microRNA (miRNA) gene repertoire. These evolutionarily novel miRNAs were primarily expressed in adult neuronal tissues and during the development and had conserved and thus likely functional target sites. The only comparable miRNA expansions happened, notably, in vertebrates. Thus, we propose that miRNAs are intimately linked to the evolution of complex animal brains.
Keywords:Brain, Messenger RNA, MicroRNAs, Seafood, Animals, Octopodiformes
Source:Science Advances
Publisher:American Association for the Advancement of Science
Page Range:eadd9938
Date:25 November 2022
Official Publication:https://doi.org/10.1126/sciadv.add9938
PubMed:View item in PubMed

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