ABVD vs BEACOPP escalated in advanced-stage Hodgkin's lymphoma: Results from a multicenter European study

Item Type:	Article
Title:	ABVD vs BEACOPP escalated in advanced-stage Hodgkin's lymphoma: Results from a multicenter European study
Creators Name:	Mondello, P. and Musolino, C. and Dogliotti, I. and Bohn, J.P. and Cavallo, F. and Ferrero, S. and Botto, B. and Cerchione, C. and Nappi, D. and De Lorenzo, S. and Martinelli, G. and Wolf, D. and Schmitt, C. and Loseto, G. and Cuzzocrea, S. and Willenbacher, W. and Mian, M. and Straus, D.J.
Abstract:	The optimal first-line treatment for advanced-stage Hodgkin's lymphoma (HL) is still a matter of debate. While ABVD is less toxic and as effective as other, more intensive chemotherapy regimens, escalated BEACOPP (BEACOPPesc) is superior to ABVD for initial disease control and prolonged time-to-relapse. However, this advantage is associated with higher rate of early and late toxicities. As most of these data have been accumulated from clinical trials, a retrospective analysis was conducted in a large database of patients treated outside clinical trials to investigate the advantages and disadvantages of these regimes in a real-world setting. From October 2009 to October 2018, 397 advanced-stage HL patients treated with either ABVD or BEACOPPesc were retrospectively assessed in 7 European cancer centers (2 Austrian and 5 Italian centers). Complete metabolic remission (CMR) by PET was achieved in 76% and 85% of patients in the ABVD and BEACOPPesc groups, respectively (p = .01). Severe adverse events occurred more frequently with BEACOPPesc than ABVD. At a median follow-up of 8 years, 9% of the patients who achieved CMR after BEACOPPesc relapsed compared to 16.6% in the ABVD group (p = .043). No statistical difference in progression free survival (PFS) was observed between the two cohorts overall (p = .11), but there was a trend towards a superior PFS in high-risk patients treated with BEACOPPesc (p = .074). Nevertheless, overall survival was similar between the two groups (p = .94). In conclusion, we confirm that ABVD is an effective and less toxic therapeutic option for advanced-stage HL. Although BEACOPP results in better initial tumor control, the long-term outcome remains similar between the two regimens.
Keywords:	Antineoplastic Combined Chemotherapy Protocols, Austria, Bleomycin, Cyclophosphamide, Dacarbazine, Disease-Free Survival, Doxorubicin, Etoposide, Follow-Up Studies, Hodgkin Disease, Italy, Neoplasm Staging, Prednisone, Procarbazine, Survival Rate, Vinblastine, Vincristine
Source:	American Journal of Hematology
ISSN:	0361-8609
Publisher:	Wiley
Volume:	95
Number:	9
Page Range:	1030-1037
Date:	September 2020
Official Publication:	https://doi.org/10.1002/ajh.25871
PubMed:	View item in PubMed

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