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Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer's disease

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Item Type:Article
Title:Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer's disease
Creators Name:Fernández Zapata, C. and Giacomello, G. and Spruth, E.J. and Middeldorp, J. and Gallaccio, G. and Dehlinger, A. and Dames, C. and Leman, J.K.H. and van Dijk, R.E. and Meisel, A. and Schlickeiser, S. and Kunkel, D. and Hol, E.M. and Paul, F. and Parr, M.K. and Priller, J. and Böttcher, C.
Abstract:Myeloid cells are suggested as an important player in Alzheimer´s disease (AD). However, its continuum of phenotypic and functional changes across different body compartments and their use as a biomarker in AD remains elusive. Here, we perform multiple state-of-the-art analyses to phenotypically and metabolically characterize immune cells between peripheral blood (n = 117), cerebrospinal fluid (CSF, n = 117), choroid plexus (CP, n = 13) and brain parenchyma (n = 13). We find that CSF cells increase expression of markers involved in inflammation, phagocytosis, and metabolism. Changes in phenotype of myeloid cells from AD patients are more pronounced in CP and brain parenchyma and upon in vitro stimulation, suggesting that AD-myeloid cells are more vulnerable to environmental changes. Our findings underscore the importance of myeloid cells in AD and the detailed characterization across body compartments may serve as a resource for future studies focusing on the assessment of these cells as biomarkers in AD.
Keywords:Alzheimer Disease, Biomarkers, Choroid Plexus, Myeloid Cells, Myeloid Progenitor Cells, Phenotype
Source:Nature Communications
Publisher:Nature Publishing Group
Page Range:7210
Date:23 November 2022
Official Publication:https://doi.org/10.1038/s41467-022-34719-2
PubMed:View item in PubMed

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