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A cFLIP-flop switch for senolysis

Item Type:Editorial
Title:A cFLIP-flop switch for senolysis
Creators Name:Fan, D.N.Y. and Schmitt, C.A.
Abstract:Persistent senescent cancer cells have tumor-promoting potential, making their selective elimination a prime therapeutic objective. The death receptor inhibitor cFLIP has now been shown to counter the susceptibility of senescent cells to DR5-mediated extrinsic apoptosis, which can be therapeutically exploited.
Keywords:Apoptosis, CASP8 and FADD-Like Apoptosis Regulating Protein
Source:Nature Cancer
ISSN:2662-1347
Publisher:Springer Nature
Volume:3
Number:11
Page Range:1279-1281
Date:November 2022
Official Publication:https://doi.org/10.1038/s43018-022-00455-1
PubMed:View item in PubMed

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