Validation and performance assessment of a preclinical SiPM-based SPECT/MRI insert

Item Type:	Article
Title:	Validation and performance assessment of a preclinical SiPM-based SPECT/MRI insert
Creators Name:	Carminati, M. and Baratelli, F.M. and Occhipinti, M. and Erlandsson, K. and Nagy, K. and Nyitrai, Z. and Czeller, M. and Kühne, A. and Niendorf, T. and Valtorta, S. and Belloli, S. and Moresco, R.M. and Savi, A. and Iadanza, A. and Falini, A. and Politi, L.S. and Cadioli, M. and Hutton, B.F. and Fiorini, C.
Abstract:	A preclinical insert for small animal simultaneous SPECT and MR imaging, in particular for imaging mouse brains, is presented. It consists of ten static magnetic resonance imaging (MRI)-compatible gamma cameras based on tiles of silicon photomultipliers readout by a multichannel ASIC and coupled to 5 cm × 5 cm CsI(Tl) scintillators and to an MRI-compatible multipinhole collimator. Calibration and image reconstruction algorithm are illustrated. Mutual compatibility is demonstrated along with imaging performance that is comparable with other non-MR micro-SPECT systems: 0.9 mm tomographic spatial resolution across a transverse field of view of 15.6 mm, 12% energy resolution (at 140 keV), and 1105 cps/MBq sensitivity. Experimental results with phantoms (glass capillaries of 290 μm diameter and a mini Derenzo) are presented.
Keywords:	Gamma Camera, Multimodal Imaging, Multipinhole Collimator, Silicon Photomultipliers (SiPMs)
Source:	IEEE Transactions on Radiation and Plasma Medical Sciences
ISSN:	2469-7311
Publisher:	IEEE
Volume:	3
Number:	4
Page Range:	483-490
Date:	July 2019
Official Publication:	https://doi.org/10.1109/TRPMS.2019.2893377

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