Validation and performance assessment of a preclinical SiPM-based SPECT/MRI insert

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Item Type:	Article
Title:	Validation and performance assessment of a preclinical SiPM-based SPECT/MRI insert
Creators Name:	Carminati, M., Baratelli, F.M., Occhipinti, M., Erlandsson, K., Nagy, K., Nyitrai, Z., Czeller, M., Kühne, A., Niendorf, T., Valtorta, S., Belloli, S., Moresco, R.M., Savi, A., Iadanza, A., Falini, A., Politi, L.S., Cadioli, M., Hutton, B.F. and Fiorini, C.
Abstract:	A preclinical insert for small animal simultaneous SPECT and MR imaging, in particular for imaging mouse brains, is presented. It consists of ten static magnetic resonance imaging (MRI)-compatible gamma cameras based on tiles of silicon photomultipliers readout by a multichannel ASIC and coupled to 5 cm × 5 cm CsI(Tl) scintillators and to an MRI-compatible multipinhole collimator. Calibration and image reconstruction algorithm are illustrated. Mutual compatibility is demonstrated along with imaging performance that is comparable with other non-MR micro-SPECT systems: 0.9 mm tomographic spatial resolution across a transverse field of view of 15.6 mm, 12% energy resolution (at 140 keV), and 1105 cps/MBq sensitivity. Experimental results with phantoms (glass capillaries of 290 μm diameter and a mini Derenzo) are presented.
Keywords:	Gamma Camera, Multimodal Imaging, Multipinhole Collimator, Silicon Photomultipliers (SiPMs)
Source:	IEEE Transactions on Radiation and Plasma Medical Sciences
ISSN:	2469-7311
Publisher:	IEEE
Volume:	3
Number:	4
Page Range:	483-490
Date:	July 2019
Official Publication:	https://doi.org/10.1109/TRPMS.2019.2893377

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