Targeted sequencing using a 47 gene multiple myeloma mutation panel (M(3) P) in -17p high risk disease

Item Type:	Article
Title:	Targeted sequencing using a 47 gene multiple myeloma mutation panel (M(3) P) in -17p high risk disease
Creators Name:	Kortüm, K.M. and Langer, C. and Monge, J. and Bruins, L. and Egan, J.B. and Zhu, Y.X. and Shi, C.X. and Jedlowski, P. and Schmidt, J. and Ojha, J. and Bullinger, L. and Liebisch, P. and Kull, M. and Champion, M.D. and Van Wier, S. and Ahmann, G. and Rasche, L. and Knop, S. and Fonseca, R. and Einsele, H. and Stewart, A.K. and Braggio, E.
Abstract:	We constructed a multiple myeloma (MM)-specific gene panel for targeted sequencing and investigated 72 untreated high-risk (del17p) MM patients. Mutations were identified in 78% of the patients. While the majority of studied genes were mutated at similar frequency to published literature, the prevalence of TP53 mutation was increased (28%) and no mutations were found in FAM46C. This study provides a comprehensive insight into the mutational landscape of del17p high-risk MM. Additionally, our work demonstrates the practical use of a customized sequencing panel, as an easy, cheap and fast approach to characterize the mutational profile of MM.
Keywords:	Myeloma, Cancer Genetics, DNA Mutation, DRUG Resistance, Genetic Analysis
Source:	British Journal of Haematology
ISSN:	0007-1048
Publisher:	Wiley-Blackwell
Volume:	168
Number:	4
Page Range:	507-510
Date:	February 2015
Official Publication:	https://doi.org/10.1111/bjh.13171
PubMed:	View item in PubMed

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