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| Item Type: | Article |
|---|---|
| Title: | Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia |
| Creators Name: | Schneider, E. and Staffas, A. and Röhner, L. and Malmberg, E.D. and Ashouri, A. and Krowiorz, K. and Pochert, N. and Miller, C. and Wei, S.Y. and Arabanian, L. and Buske, C. and Döhner, H. and Bullinger, L. and Fogelstrand, L. and Heuser, M. and Döhner, K. and Xiang, P. and Ruschmann, J. and Petriv, O.I. and Heravi-Moussavi, A. and Hansen, C.L. and Hirst, M. and Humphries, R.K. and Rouhi, A. and Palmqvist, L. and Kuchenbauer, F. |
| Abstract: | Micro-ribonucleic acid-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis of acute myeloid leukemia. We found miR-155 to be a direct target of Meis1 in murine Hoxa9/Meis1 induced acute myeloid leukemia. The additional overexpression of miR-155 accelerated the formation of acute myeloid leukemia in Hoxa9 as well as in Hoxa9/Meis1 cells However, in the absence or following the removal of miR-155, leukemia onset and progression were unaffected. Although miR-155 accelerated growth and homing in addition to impairing differentiation, our data underscore the pathophysiological relevance of miR-155 as an accelerator rather than a driver of leukemogenesis. This further highlights the complexity of the oncogenic program of Meis1 to compensate for the loss of a potent oncogene such as miR-155. These findings are highly relevant to current and developing approaches for targeting miR-155 in acute myeloid leukemia. |
| Keywords: | Carcinogenesis, Leukemic Gene Expression Regulation, Homeodomain Proteins, Acute Myeloid Leukemia, MicroRNAs, Myeloid Ecotropic Viral Integration Site 1 Protein / Pharmacology, Animals, Mice |
| Source: | Haematologica |
| ISSN: | 0390-6078 |
| Publisher: | Ferrata Storti Foundation |
| Volume: | 103 |
| Number: | 2 |
| Page Range: | 246-255 |
| Date: | February 2018 |
| Official Publication: | https://doi.org/10.3324/haematol.2017.177485 |
| PubMed: | View item in PubMed |
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