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| Item Type: | Article |
|---|---|
| Title: | Association of obesity with disease outcome in multiple sclerosis |
| Creators Name: | Lutfullin, I. and Eveslage, M. and Bittner, S. and Antony, G. and Flaskamp, M. and Luessi, F. and Salmen, A. and Gisevius, B. and Klotz, L. and Korsukewitz, C. and Berthele, A. and Groppa, S. and Then Bergh, F. and Wildemann, B. and Bayas, A. and Tumani, H. and Meuth, S.G. and Trebst, C. and Zettl, U.K. and Paul, F. and Heesen, C. and Kuempfel, T. and Gold, R. and Hemmer, B. and Zipp, F. and Wiendl, H. and Lünemann, J.D. |
| Abstract: | BACKGROUND: Obesity reportedly increases the risk for developing multiple sclerosis (MS), but little is known about its association with disability accumulation. METHODS: This nationwide longitudinal cohort study included 1066 individuals with newly diagnosed MS from the German National MS cohort. Expanded Disability Status Scale (EDSS) scores, relapse rates, MRI findings and choice of immunotherapy were compared at baseline and at years 2, 4 and 6 between obese (body mass index, BMI ≥30 kg/m2) and non-obese (BMI <30 kg/m2) patients and correlated with individual BMI values. RESULTS: Presence of obesity at disease onset was associated with higher disability at baseline and at 2, 4 and 6 years of follow-up (p<0.001). Median time to reach EDSS 3 was 0.99 years for patients with BMI ≥30 kg/m2 and 1.46 years for non-obese patients. Risk to reach EDSS 3 over 6 years was significantly increased in patients with BMI ≥30 kg/m2 compared with patients with BMI <30 kg/m2 after adjustment for sex, age, smoking (HR 1.87; 95% CI 1.3 to 2.6; log-rank test p<0.001) and independent of disease-modifying therapies. Obesity was not significantly associated with higher relapse rates, increased number of contrast-enhancing MRI lesions or higher MRI T2 lesion burden over 6 years of follow-up. CONCLUSIONS: Obesity in newly diagnosed patients with MS is associated with higher disease severity and poorer outcome. Obesity management could improve clinical outcome of MS. |
| Keywords: | Disease Progression, Longitudinal Studies, Magnetic Resonance Imaging, Multiple Sclerosis, Relapsing-Remitting Multiple Sclerosis, Obesity, Recurrence |
| Source: | Journal of Neurology Neurosurgery and Psychiatry |
| ISSN: | 0022-3050 |
| Publisher: | BMJ Publishing Group |
| Volume: | 94 |
| Number: | 1 |
| Page Range: | 57-61 |
| Date: | January 2023 |
| Official Publication: | https://doi.org/10.1136/jnnp-2022-329685 |
| PubMed: | View item in PubMed |
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