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Transcriptional mechanisms of pancreatic β-cell maturation and functional adaptation

Item Type:Review
Title:Transcriptional mechanisms of pancreatic β-cell maturation and functional adaptation
Creators Name:Wortham, M. and Sander, M.
Abstract:Pancreatic β-cells secrete insulin commensurate to circulating nutrient levels to maintain normoglycemia. The ability of β-cells to couple insulin secretion to nutrient stimuli is acquired during a postnatal maturation process. In mature β-cells the insulin secretory response adapts to changes in nutrient state. Both β-cell maturation and functional adaptation rely on the interplay between extracellular cues and cell type-specific transcriptional programs. Here we review emerging evidence that developmental and homeostatic regulation of β-cell function involves collaboration between lineage-determining and signal-dependent transcription factors (LDTFs and SDTFs, respectively). A deeper understanding of β-cell SDTFs and their cognate signals would delineate mechanisms of β-cell maturation and functional adaptation, which has direct implications for diabetes therapies and for generating mature β-cells from stem cells.
Keywords:Cell Differentiation, Insulin, Insulin Secretion, Insulin-Secreting Cells, Stem Cells
Source:Trends in Endocrinology and Metabolism
Page Range:474-487
Date:July 2021
Official Publication:https://doi.org/10.1016/j.tem.2021.04.011
PubMed:View item in PubMed

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