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Nomenclature for cellular plasticity: are the terms as plastic as the cells themselves?

Item Type:Editorial
Title:Nomenclature for cellular plasticity: are the terms as plastic as the cells themselves?
Creators Name:Mills, J.C. and Stanger, B.Z. and Sander, M.
Abstract:It is now recognized that cell identity is more fluid, and tissues more plastic, than previously thought. The plasticity of cells is relevant to diverse fields, most notably developmental and stem cell biology, regenerative medicine, and cancer biology. To date, a comprehensive and uniform nomenclature to define distinct cell states and their injury-induced interconversions has been elusive. The first Keystone Symposium devoted exclusively to cellular plasticity in regeneration and tumorigenesis was held on January 2019 in Keystone, Colorado, and featured a workshop on terminology in the cell plasticity field. Definitions for terms such as plasticity, de- and transdifferentiation, reversion, and paligenosis were discussed. Here, we summarize the content and tenor of the symposium and nomenclature-focused workshop with regard to terms in the field. We outline the challenges with current definitions and recommend best practices and approaches to developing an accurate and acceptable nomenclature in the future.
Keywords:Carcinogenesis, Cell Plasticity, Congresses as Topic, Plastics, Regenerative Medicine, Terminology as Topic, Animals
Source:EMBO Journal
Publisher:EMBO Press / Wiley
Page Range:e103148
Date:1 October 2019
Official Publication:https://doi.org/10.15252/embj.2019103148
PubMed:View item in PubMed

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