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Pancreas organogenesis: from lineage determination to morphogenesis

Item Type:Review
Title:Pancreas organogenesis: from lineage determination to morphogenesis
Creators Name:Shih, H.P. and Wang, A. and Sander, M.
Abstract:The pancreas is an essential organ for proper nutrient metabolism and has both endocrine and exocrine function. In the past two decades, knowledge of how the pancreas develops during embryogenesis has significantly increased, largely from developmental studies in model organisms. Specifically, the molecular basis of pancreatic lineage decisions and cell differentiation is well studied. Still not well understood are the mechanisms governing three-dimensional morphogenesis of the organ. Strategies to derive transplantable β-cells in vitro for diabetes treatment have benefited from the accumulated knowledge of pancreas development. In this review, we provide an overview of the current understanding of pancreatic lineage determination and organogenesis, and we examine future implications of these findings for treatment of diabetes mellitus through cell replacement.
Keywords:Pancreas, Development, Progenitor, Exocrine, Endocrine, Pluripotent Stem Cell, Animals
Source:Annual Review of Cell and Developmental Biology
Publisher:Annual Reviews
Page Range:81-105
Date:October 2013
Official Publication:https://doi.org/10.1146/annurev-cellbio-101512-122405
PubMed:View item in PubMed

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