Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas

Item Type:	Article
Title:	Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
Creators Name:	Sander, M. and Sussel, L. and Conners, J. and Scheel, D. and Kalamaras, J. and Dela Cruz, F. and Schwitzgebel, V. and Hayes-Jordan, A. and German, M.
Abstract:	Most insulin-producing beta-cells in the fetal mouse pancreas arise during the secondary transition, a wave of differentiation starting at embryonic day 13. Here, we show that disruption of homeobox gene Nkx6.1 in mice leads to loss of beta-cell precursors and blocks beta-cell neogenesis specifically during the secondary transition. In contrast, islet development in Nkx6. 1/Nkx2.2 double mutant embryos is identical to Nkx2.2 single mutant islet development: beta-cell precursors survive but fail to differentiate into beta-cells throughout development. Together, these experiments reveal two independently controlled pathways for beta-cell differentiation, and place Nkx6.1 downstream of Nkx2.2 in the major pathway of beta-cell differentiation.
Keywords:	Islet, ß-Cell, Insulin, Transcription Factor, Mouse, Animals, Mice
Source:	Development
ISSN:	0950-1991
Publisher:	Company of Biologists
Volume:	127
Number:	24
Page Range:	5533-40
Date:	December 2000
Official Publication:	https://doi.org/10.1242/dev.127.24.5533
PubMed:	View item in PubMed

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