Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates

Item Type:	Article
Title:	Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates
Creators Name:	Sander, M. and Paydar, S. and Ericson, J. and Briscoe, J. and Berber, E. and German, M. and Jessell, T.M. and Rubenstein, J.L.
Abstract:	There is growing evidence that sonic hedgehog (Shh) signaling regulates ventral neuronal fate in the vertebrate central nervous system through Nkx-class homeodomain proteins. We have examined the patterns of neurogenesis in mice carrying a targeted mutation in Nkx6.1. These mutants show a dorsal-to-ventral switch in the identity of progenitors and in the fate of postmitotic neurons. At many axial levels there is a complete block in the generation of V2 interneurons and motor neurons and a compensatory ventral expansion in the domain of generation of V1 neurons, demonstrating the essential functions of Nkx6.1 in regional patterning and neuronal fate determination.
Keywords:	Nkx, Spinal Cord, Motor Neurons, Neuronal Specification, Interneurons, Animals, Mice
Source:	Genes and Development
ISSN:	0890-9369
Publisher:	Cold Spring Harbor Laboratory Press
Volume:	14
Number:	17
Page Range:	2134-9
Date:	1 September 2000
Official Publication:	https://doi.org/10.1101/gad.820400
PubMed:	View item in PubMed

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