The MafA transcription factor appears to be responsible for tissue-specific expression of insulin

Item Type:	Article
Title:	The MafA transcription factor appears to be responsible for tissue-specific expression of insulin
Creators Name:	Matsuoka, T. and Artner, I. and Henderson, E. and Means, A. and Sander, M. and Stein, R.
Abstract:	Insulin gene expression is regulated by several islet-enriched transcription factors. However, MafA is the only beta cell-specific activator. Here, we show that MafA selectively induces endogenous insulin transcription in non-beta cells. MafA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MafA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.
Keywords:	Base Sequence, Cell Line, DNA Primers, Gene Expression Regulation, Immunohistochemistry, Insulin, Islets of Langerhans, C-Type Lectins, Large Maf Transcription Factors, Molecular Sequence Data, Organ Specificity, Immunologic Receptors, Recombinant Proteins, Trans-Activators, Transcription Factors, Transfection, Animals, Mice, Rats
Source:	Proceedings of the National Academy of Sciences of the United States of America
ISSN:	0027-8424
Publisher:	National Academy of Sciences
Volume:	101
Number:	9
Page Range:	2930-3
Date:	2 March 2004
Official Publication:	https://doi.org/10.1073/pnas.0306233101
PubMed:	View item in PubMed

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