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The MafA transcription factor appears to be responsible for tissue-specific expression of insulin

Item Type:Article
Title:The MafA transcription factor appears to be responsible for tissue-specific expression of insulin
Creators Name:Matsuoka, T., Artner, I., Henderson, E., Means, A., Sander, M. and Stein, R.
Abstract:Insulin gene expression is regulated by several islet-enriched transcription factors. However, MafA is the only beta cell-specific activator. Here, we show that MafA selectively induces endogenous insulin transcription in non-beta cells. MafA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MafA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.
Keywords:Base Sequence, Cell Line, DNA Primers, Gene Expression Regulation, Immunohistochemistry, Insulin, Islets of Langerhans, C-Type Lectins, Large Maf Transcription Factors, Molecular Sequence Data, Organ Specificity, Immunologic Receptors, Recombinant Proteins, Trans-Activators, Transcription Factors, Transfection, Animals, Mice, Rats
Source:Proceedings of the National Academy of Sciences of the United States of America
ISSN:0027-8424
Publisher:National Academy of Sciences
Volume:101
Number:9
Page Range:2930-3
Date:2 March 2004
Official Publication:https://doi.org/10.1073/pnas.0306233101
PubMed:View item in PubMed

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